Current Issue : July - September Volume : 2013 Issue Number : 3 Articles : 5 Articles
To explore variation in relationship between VIQ and psychopathologies before and after treatment. In 46 cases of acute schizophrenic Indian subjects diagnosed on ICD-10/DSM IV TR criteria were measured on SANS (Scale for Assessment of Negative Symptoms), SAPS (Scale for Assessment of Positive symptoms) and WAIS-R (Indian adaptation) Wechsler’s Adult Intelligence scale-Revised before and after treatment. The result showed persistent negative relationship between the verbal intelligence and psychopathologies was maintained pre and post treatment throughout the study. But different respondents such as attention-impairment, delusion bizarre behavior and SAPS (total) had insignificant negative relationship. The formal thought disorder changed from negative to positive after treatment....
Keratitis is a condition in which the cornea of the eye becomes inflamed. It is caused by Bacteria, Viruses, Fungi and Parasites. This study investigate that the evaluation the clinical isolates and microbial diagnosis of keratitis causing microorganism using 16SrDNA and 18SrDNA gene sequencing for bacteria and fungi from infectious eye sample of keratitis patients. All keratitis subjects were examined with a slit lamp biomicroscope in the Eye Clinic of the General Hospital of Tiruchirappalli. The Bacteria and fungus were isolated in eye swabs of keratitis patients. The bacterial and fungal genes were sequenced by using 16S rRNA and 18S rRNA- PCR. These sequences were identified using BLASTn (Basic Local Alignment Search Tool nucleotide) and deposited in the GenBank (NCBI) with the accession numbers Staphylococcus aureus (JN378392), Staphylococcus epidermidis (HQ404365), Micrococcus sp.(HM20450), Streptococcus viridians(JN378393), Moraxella sp.(JQ039348), Propionibacterium acnes (JQ039349), Acinetobacter baumanii (JN652129), Citrobacter koseri (JN652127), Pseudomonas aeruginosa(JQ039350), Klebsiella sp.(JN652128) and flavobacterium (JN835368) whereas fungal genes such as Fusarium sp.(JQ412816), Candida albicans (JX912562), Aspergillus sp.(JX204747), Sebipora aquosa (submitted) Byssochlamys nivea (Submitted). Eleven bacterial strains and five fungal strains were identified and the results in our study may be useful for further research about molecular characterizing studies....
The aim of this study was to analyze the pattern of prescription and determine causative factors of Dry eye disease and Scleritis. Evaluation of eye dryness after cataract surgery for determine association with intraoperative risk factors. The prospective study was performed by including 150 Dry eye disease and 80 Scleritis patients at sat Kaival hospital, Sarsa. During December 2012 to April 2013, Demographic data of all patients were collected and distributed as age groups and gender, females were distributed according to pre and post menopausal time. Evaluation of eye dryness after cataract surgery was performed for determined intra operative risk factors. Association of Episcleritis and Anterior scleritis with Rheumatoid arthritis had determined by dividing the patients in both types of Scleritis. The study was found 38% male and 62% females of Dry eye disease diagnosed by Schirmer test-I, post- menopausal women 73.11% were more than pre -menopausal women 26.88%. Diabetes 30% and cataract 30.66% were more associated with Dry eye disease. Artificial tears 56.39% were more preferable drugs according to this study. SICS significantly increase dryness of the eye (p value <0.05). Scleritis was ocular inflammation, frequently occur in RA (rheumatoid arthritis patients) patients, however Episcleritis significantly occur in non rheumatoid patients. Dry eye disease was multifactorial disease, menopause and old age might have effect on Dry eye disease. Post menopausal and elderly patients were comparatively higher. SICS significantly led dryness. Episcleritis was more found in non rheumatoid patients while Anterior scleritis was in rheumatoid patients....
Background: Qualitative research methods are increasingly used within clinical trials to address broader research\r\nquestions than can be addressed by quantitative methods alone. These methods enable health professionals,\r\nservice users, and other stakeholders to contribute their views and experiences to evaluation of healthcare\r\ntreatments, interventions, or policies, and influence the design of trials. Qualitative data often contribute information\r\nthat is better able to reform policy or influence design.\r\nMethods: Health services researchers, including trialists, clinicians, and qualitative researchers, worked\r\ncollaboratively to develop a comprehensive portfolio of standard operating procedures (SOPs) for the West Wales\r\nOrganisation for Rigorous Trials in Health (WWORTH), a clinical trials unit (CTU) at Swansea University, which has\r\nrecently achieved registration with the UK Clinical Research Collaboration (UKCRC). Although the UKCRC requires a\r\ntotal of 25 SOPs from registered CTUs, WWORTH chose to add an additional qualitative-methods SOP (QM-SOP).\r\nResults: The qualitative methods SOP (QM-SOP) defines good practice in designing and implementing qualitative\r\ncomponents of trials, while allowing flexibility of approach and method. Its basic principles are that: qualitative\r\nresearchers should be contributors from the start of trials with qualitative potential; the qualitative component\r\nshould have clear aims; and the main study publication should report on the qualitative component.\r\nConclusions: We recommend that CTUs consider developing a QM-SOP to enhance the conduct of quantitative\r\ntrials by adding qualitative data and analysis. We judge that this improves the value of quantitative trials, and\r\ncontributes to the future development of multi-method trials....
Stage-1 hypertensive patients often require combination therapy to achieve a blood pressure (BP) goal and evidence suggests that time to BP goal is crucial to decrease cardiovascular risk. The aim of the study was to investigate whether the single-pill combination of Telmisartan and Amlodipine was superior to Telmisartan and Hydrochlorothiazide as initial antihypertensive therapy in patients with stage-1 hypertension. An 8-week, randomized, parallel-group, single-blind trial comparing the once daily Single-pill combination of Telmisartan 40 mg and Amlodipine 5 mg (T40/A5; n=30) with once-daily Telmisartan 40 mg and Hydrochlorothiazide 12.5 mg (T40/H12.5: n=30) in patients with stage-1 hypertension. Patient demographics were similar between treatment groups, with MeanSEM of age was 57.21.882 for T40/A5 group and 51.831.851 for T40/H12.5H group, the MeanSEM of body mass index was 24.250.5310 for T40/A5 group and 26.230.9600 for T40/H12.5 group. Significantly greater reduction in the MeanSEM of SBP and DBP (25.790.6962 mmHg and 14.480.3545 mmHg) for T40/A5 group as compared to T40/H12.5 group (19.290.7289 mmHg and 7.920.3274 mmHg) were achieved (P< 0.0001). After 8 weeks, 89.5% versus 76.8% of patients achieved the BP goal (<140/90 mm Hg) with T40/A5 versus T40/H12.5. The most common adverse events were peripheral edema, headache, and dizziness, observed. In the patients with stage-1 hypertension, T40/A5 provided significant and greater BP reduction compared with T40/H12.5 therapy, with the majority of patients achieving the BP goal (<140/90 mm Hg)....
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